數(shù)據(jù)庫(kù)官網(wǎng)
小程序
打開微信掃一掃
首頁(yè)
分子通
化學(xué)資訊
化學(xué)百科
反應(yīng)查詢
關(guān)于我們
請(qǐng)輸入關(guān)鍵詞
歷史搜索
熱門化合物HOT
- 喹啉
- 水楊醛
- 二溴甲烷
- 谷胱甘肽
- L-乳酸
- 苯巴比妥
- 辣椒堿
- 非那明
- 百草枯
- 聯(lián)苯烯
林可胺類藥
藥物分類
該類藥物包括林可霉素及其半合成衍生物克林霉素兩個(gè)品種。
作用機(jī)制林可霉素類主要作用于細(xì)菌核糖體的50S亞基，通過(guò)抑制肽鏈延長(zhǎng)干擾細(xì)菌蛋白質(zhì)合成，屬于生長(zhǎng)期抑菌劑。其抗菌譜與紅霉素相似但較窄，主要包括：
- 革蘭陽(yáng)性菌：包括葡萄球菌屬（包括耐青霉素株）、鏈球菌屬、白喉?xiàng)U菌和炭疽桿菌等。
- 厭氧菌：如脆弱擬桿菌、梭桿菌屬、消化球菌、消化鏈球菌以及產(chǎn)氣莢膜桿菌等。
- 革蘭陰性需氧菌，如流感嗜血桿菌、奈瑟菌屬及支原體屬均對(duì)其耐藥。
細(xì)菌對(duì)林可霉素與克林霉素之間存在完全交叉耐藥性，而與紅霉素間則有部分交叉耐藥性。
臨床應(yīng)用這類藥物主要用于治療由厭氧菌和革蘭陽(yáng)性球菌引起的感染，如肺炎、心內(nèi)膜炎、蜂窩織炎、丹毒及泌尿系統(tǒng)感染等。特別適用于治療因厭氧菌引起的各種感染以及金黃色葡萄球菌性骨髓炎的首選治療藥。
| 中文名稱 | 英文名稱 | CAS號(hào) | 化學(xué)式 |
|---|---|---|---|
| 鹽酸林可霉素(一水物) | lincomycin hydrochloride hydrate | 7179-49-9 | C18H34N2O6S*ClH*2H2O |
| 鹽酸林可霉素 | lincomycin hydrochloride | 859-18-7 | C18H34N2O6S*ClH |
| 鹽酸克林霉素 | clindamycin hydrochloride | 21462-39-5 | C18H33ClN2O5S*ClH |
| 棕櫚氯林可霉素鹽酸鹽 | clindamycin palmitate hydrochloride | 25507-04-4 | C34H63ClN2O6S*ClH |
| 林可霉素 | lincomycin | 17017-22-0 | C18H34N2O6S |
| 林可霉素 | lincomycin | 154-21-2 | C18H34N2O6S |
| 克林霉素磷酸酯 | clindamycin phosphate | 24729-96-2 | C18H34ClN2O8PS |
| 克林霉素 | clindamycin | 18323-44-9 | C18H33ClN2O5S |
| —— | 7-Chlor-7-deoxylincomycin | 16684-06-3 | C18H33ClN2O5S |
| —— | [6-[2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate | 24729-96-2 | C18H34ClN2O8PS |
| —— | Cleocin | 21462-39-5 | C18H34Cl2N2O5S |
| —— | (2S,4R)-N-[(1S,2S)-2-Hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | 859-18-7 | C18H35ClN2O6S |
| —— | (2S,4R)-N-[2-chloro-1-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | 21462-39-5 | C18H34Cl2N2O5S |
| —— | (2S,4R)-N-[2-hydroxy-1-[(3R,4S,5S)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | 859-18-7 | C18H35ClN2O6S |
| —— | [(2S,3S,4R,5S,6S)-6-[(1R)-2-chloro-1-[[(2R,4S)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate | 24729-96-2 | C18H34ClN2O8PS |
| —— | Cleocin HCL Monohydrate | 21462-39-5 | C18H34Cl2N2O5S |
| —— | [(4S,5R)-6-[2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate | 24729-96-2 | C18H34ClN2O8PS |
| —— | Pharmakon1600-01505470 | 25507-04-4 | C34H64Cl2N2O6S |
| —— | [(2R,3R,4S,5R)-6-[2-chloro-1-[[(2S)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] hexadecanoate;hydrochloride | 25507-04-4 | C34H64Cl2N2O6S |
| —— | (2S,4R)-N-[2-hydroxy-1-[(3R,4R,5S)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | 859-18-7 | C18H35ClN2O6S |
| —— | (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride | 859-18-7 | C18H35ClN2O6S |
| —— | [(2S,3S,4R,5S,6S)-6-[(1R,2R)-2-chloro-1-[[(2R,4S)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate | 24729-96-2 | C18H34ClN2O8PS |
| —— | (4R)-N-[(1S,2S)-2-chloro-1-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride | 21462-39-5 | C18H34Cl2N2O5S |
| —— | N-Demethyllincomycin | 2256-16-8 | C17H32N2O6S |
| —— | Lincocin | 859-18-7 | C18H35ClN2O6S |
| —— | lincomycin | 154-21-2 | C18H34N2O6S |
| —— | lincomycin hydrochloride | 859-18-7 | C18H34N2O6S*ClH |
| —— | Clindamycin-2-palmitat-hydrochlorid | 25507-04-4 | C34H63ClN2O6S*ClH |
| —— | (2S,4R)-N-{2-chloro-1-[(2R,3R,4S,5R,6R)-3,4-dihydroxy-6-(methylsulfanyl)-5-(phosphonooxy)oxan-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboximidic acid | 24729-96-2 | C18H34ClN2O8PS |
| —— | Clindamycin-2-phosphat | 24729-96-2 | C18H34ClN2O8PS |
| —— | [6-[2-Chloro-1-[(1-methyl-4-propylpyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate | 24729-96-2 | C18H34ClN2O8PS |
| —— | (2S,4R)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-4-propylpyrrolidine-2-carboxamide | 2256-16-8 | C17H32N2O6S |
聯(lián)系我們
關(guān)注我們
公眾號(hào)
友情鏈接: 摩熵化學(xué) 摩熵化學(xué)數(shù)據(jù)庫(kù) 960化工網(wǎng) 中華試劑網(wǎng)