抗生素是一類用于治療細菌感染的化合物,廣泛應用于臨床醫學和獸醫領域。除了青霉素、頭孢菌素等廣為人知的抗生素外,還有多種其它類型的抗生素在臨床上發揮重要作用。
大環內酯類抗生素大環內酯類抗生素是由鏈霉菌產生的次級代謝產物,代表藥物包括紅霉素、阿奇霉素和克拉霉素。這類抗生素通過與細菌核糖體50S亞基結合,抑制蛋白質合成,從而起到抗菌作用。它們廣泛用于治療呼吸道感染、皮膚軟組織感染以及某些性傳播疾病。
氨基糖苷類抗生素氨基糖苷類抗生素由鏈霉菌和小單胞菌產生,代表藥物有慶大霉素、阿米卡星等。這類抗生素通過與細菌核糖體30S亞基結合,干擾蛋白質合成過程中的氨酰-tRNA的進入,導致錯誤氨基酸插入以及肽鏈過早終止。它們常用于治療革蘭氏陰性菌引起的嚴重感染。
四環素類抗生素四環素類抗生素是最早被發現并廣泛使用的廣譜抗生素之一,包括多西環素、米諾環素等。這類藥物通過與細菌核糖體30S亞基結合,抑制蛋白質合成,并且能穿透革蘭氏陰性和陽性菌的細胞壁。盡管它們具有廣泛的抗菌譜和良好的口服生物利用度,但由于潛在的肝毒性、腎毒性和牙色素沉著等不良反應,在使用時需謹慎。
氟喹諾酮類抗生素氟喹諾酮類抗生素是一類人工合成的廣譜抗菌藥物,如氧氟沙星、左氧氟沙星。它們通過抑制細菌DNA旋轉酶和拓撲異構酶IV,干擾DNA復制與重組過程。這類藥物對多種革蘭氏陽性和陰性菌有效,并且具有良好的口服吸收特性。
氯霉素類抗生素氯霉素是一類較早的廣譜抗生素,主要適用于耐藥性鏈球菌、某些厭氧菌和立克次體感染。然而由于其潛在的骨髓抑制作用(引起再生障礙性貧血),臨床應用受到一定限制。
這些不同類型的抗生素各有特點,在治療特定類型細菌感染時表現出不同的效果與副作用。因此,在使用抗生素時需要根據具體病情和細菌培養及藥敏試驗結果,合理選擇藥物種類和劑量,以達到最佳的治療效果并減少不良反應的發生。
| 中文名稱 | 英文名稱 | CAS號 | 化學式 |
|---|---|---|---|
| 馬來酸羅格列酮 | avandia | 155141-29-0 | C4H4O4*C18H19N3O3S |
| 非律平 | 15-Deoxylagosin | 480-49-9 | C35H58O11 |
| 雷夫康唑 | (1R,2R)-4-[2-[2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-thiazol-4-yl]-benzonitrile | 170864-29-6 | C22H17F2N5OS |
| 除莠霉素A | herbimycin A | 70563-58-5 | C30H42N2O9 |
| 阿霉素醇 | Doxorubicinol | 54193-28-1 | C27H31NO11 |
| 阿貝卡星 | arbekacin | 51025-85-5 | C22H44N6O10 |
| 阿莫西林三水合物 | Amoxicillin Trihydrate | 61336-70-7 | C16H25N3O8S |
| 阿莫沙平 | Pharmakon1600-01505955 | 1264-72-8 | C52H100N16O17S |
| 阿扎那韋硫酸鹽 | atazanavir sulphate | 229975-97-7 | C38H52N6O7*H2O4S |
| 阿扎那韋 | atazanavir | 198904-31-3 | C38H52N6O7 |
| 阿奇霉素 | Azithromycin Dihydrate | 117772-70-0 | C38H76N2O14 |
| 鏈脲菌素(STZ) | Zanosar | 18883-66-4 | C8H15N3O7 |
| 鏈病毒菌素 | (E)-N-[(2S,3R,4R,5R,6R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-5-methylhex-2-enamide | 11089-65-9 | C30H46N4O16 |
| 銨離子載體 I | (1R,2R,5R,7R,10S,11S,14S,16R,19R,20R,23R,25R,28S,29S,32S,34R)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone | 6833-84-7 | C40H64O12 |
| 酒石酸泰樂菌素 | tylosin tartrate | 1405-54-5 | C4H6O6*C46H77NO17 |
| 達蘆那韋 | darunavir | 206361-99-1 | C27H37N3O7S |
| 辛可尼丁 | Cinchonidin | 485-71-2 | C19H22N2O |
| 轉化酶來源于面包酵母(釀酒酵母) | Doxycycline monohydrate | 9001-57-4 | C22H26N2O9 |
| 赤霉素 A7 | gibberellin A7 | 510-75-8 | C19H22O5 |
| 表灰黃霉素 | d,l-epigriseofulvin | 469-49-8 | C17H17ClO6 |
| 茴香霉素 | (-)-anisomycin | 22862-76-6 | C14H19NO4 |
| 艾菲地可寧 | Aphidicolin | 38966-21-1 | C20H34O4 |
| 腎上腺酮 | Corticosterone | 50-22-6 | C21H30O4 |
| 纈氨霉素 | cyclo[OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-DL-Val] | 2001-95-8 | C54H90N6O18 |
| 細胞松馳素 E | cytochalasin E | 36011-19-5 | C28H33NO7 |
| 細胞松弛素H | cytochalasin H | 53760-19-3 | C30H39NO5 |
| 細胞松弛素B | cytochalasin B | 14930-96-2 | C29H37NO5 |
| 紡錘菌素 | netropsin | 1438-30-8 | C18H26N10O3 |
| 納他霉素 | natamycin | 7681-93-8 | C33H47NO13 |
| 紅霉素A9,11-亞氨基醚 | Azithromycin Impurity R | 161193-44-8 | C37H66N2O12 |
| 紅放線菌素A | 32-Ethyl-14,16,18,20,22,24,26,28-octahydroxy-15,31-dimethyl-1-oxacyclodotriaconta-3,5,7,9,11,29-hexaen-2-one | 154396-73-3 | C35H56O10 |
| 磺胺鄰二甲氧嘧啶 | sufadoxine | 2447-57-6 | C12H14N4O4S |
| 磺胺氯噠嗪 | sulfachloropyridazine | 80-32-0 | C10H9ClN4O2S |
| 磺胺吡啶 | sulphapyridine | 144-83-2 | C11H11N3O2S |
| 磺胺二甲基嘧啶 | 4,6-Dimethyl-pyrimidin-2-sulfonamid | 35762-76-6 | C6H9N3O2S |
| 磷霉素鈣 | Fosfomycin calcium monohydrate | 26016-98-8 | C3H7CaO4P |
| 磷霉素 | fosfomycin | 23155-02-4 | C3H7O4P |
| 磷酸泰樂菌素 | tylosin phosphate | 1405-53-4 | C46H77NO17*H3O4P |
| 磷酸奧司他韋 | oseltamivir phosphate | 204255-11-8 | C16H28N2O4*H3O4P |
| 硫鏈絲菌肽 | N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1R,11Z,15S,18S,25S,26R,35R,40S,46S,53S)-37-[(2S)-butan-2-yl]-18-[(2S,3R)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8-[(1R)-1-hydroxyethyl]-31-[(1S)-1-hydroxyethyl]-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide | 1393-48-2 | C72H85N19O18S5 |
| 硫酸阿米卡星 | amikacin Sulfate | 39831-55-5 | C22H43N5O13*H2O4S |
| 軟骨素硫酸鈉鹽 | (2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | 25322-46-7 | C13H21NO15S |
| 硫酸多粘菌素B | N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid | 1405-20-5 | C56H100N16O17S |
| 硫藤黃素 | thiolutin | 87-11-6 | C8H8N2O2S2 |
| 硝唑尼特 | nitazoxanide | 55981-09-4 | C12H9N3O5S |
| 硝呋酚酰肼 | nifuroxazide | 965-52-6 | C12H9N3O5 |
| 鹽酸環丙沙星(一水物) | 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate | 86393-32-0 | C17H18FN3O3*ClH*H2O |
| 鹽酸呋喃它酮 | furaltadone hydrochloride | 3759-92-0 | C13H16N4O6*ClH |
| 鹽酸原黃素 | proflavine hydrochloride | 952-23-8 | C13H11N3*ClH |
| 鹽酸佐柔比星 | Benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride | 36508-71-1 | C34H35N3O10*ClH |